You don't need any additional preamp if you are happy with the amp modelling of the GSP1101 but if you have or find a pre that you can't live without the GSP1101 is transparent and works great with a separate preamp. If you are running the official firmware from Digitech use the x-edit available from the Digitech site, if you are using the beta firmware and on windows you will need the x-edit available with the beta firmware from mutbebeta, if you are on a Mac you can use the latest official x-edit but keep in mind that it is missing all the new features found in vC48, it will load and save all the settings in your presets fine though. You need the correct x-edit for the firmware you have installed. If you wish to use other peoples presets or save your own and share them you need to install x-edit. The vC48 beta firmware is available from download the files, connect your GSP1101 to your computer and run the installer, You need a PC running windows. What other settings are you asking about?